Intraosseous Myofibroma of the Mandible in a 7-Year-Old Patient: A Case Report

Authors

  • Meshala Bala Sundram Department of Paediatric Dentistry, Hospital Tengku Ampuan Rahimah Klang, Malaysia
  • Navasheilla Retna Retnasingam Department of Paediatric Dentistry, Hospital Tengku Ampuan Rahimah Klang, Malaysia
  • Bahruddin Saripudin Department of Paediatric Dentistry, Hospital Tengku Ampuan Rahimah Klang, Malaysia
  • Zuraiza Mohamad Zaini Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry, University Malaya, Malaysia

DOI:

https://doi.org/10.51407/mjpch.v27i1.117

Keywords:

Myofibroma, Spindle cell, Biphasic growth

Abstract

Myofibroma is a benign fibrous tumour that occurs predominantly in the head and neck region followed by the trunk and extremities. However, cases occurring in the oral cavity are rare, presenting with a variable clinical appearances and wide differential diagnosis.  We reported a case of a 7-year-old girl who was referred to the Department of Paediatric Dentistry, Tengku Ampuan Rahimah Hospital with a progressively enlarging painless swelling on the left posterior region of the mandible over the past 3 months.  The swelling was associated with ulceration and displaced lower left first permanent molar.  Radiographic investigations reported well-defined radiolucency at molar area, alveolar expansion and bone resorption of the left posterior alveolar ridge of the mandible. Complete surgical excision of the lesion was performed under general anaesthesia.  Histopathological examination revealed proliferation of spindle shaped cells with biphasic growth pattern. Immunohistochemical staining showed strong positivity with vimentin and smooth muscle actin whilst negative for desmin, S100 and CD34 establishing the diagnosis of myofibroma. Although rare, myofibroma should be considered as a differential diagnosis for solitary firm swelling in the oral cavity. Histopathological examination together with immunohistochemical analysis is essential for an accurate diagnosis.

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References

Vaishali N, Syed AA, Charu S, Shahela T. Myofibroma of the Gingiva: A Rare Case Report and Literature Review. Hindawi Publishing Corporation, Case Reports in Dentistry Volume 2015, Article ID 243894, 4 pages.

Weiss SW, Goldblum JR (eds): Enzinger and Weiss’s Soft Tissue Tumors, ed. St Louis, Mosby, 2001:357-363.

Andreadis D, Epivatianos A, Samara A, Kirili T, Iordanidis F, Poulopoulos A. Myofibroma of the Oral Mucosa: A Case Report. Med Princ Pract 2012; 21:288-291.

Rubin BP, Bridge JA: Myofibroma/myofibromatosis; in Fletcher CD, Unni KK, Martene F (eds): WHO Classification of Tumors: Pathology and Genetics, Tumors of Soft Tissue and Bone. Lyon, IARC Press, 2002, pp 59-61.

Zanella TA. Intraosseous Myofibroma of The Jaw-Systematic Review. Investigacao. 2015;14:182-188.

Stout AP, Juvenile Fibromatosis. Cancer, 1954 Sep; 7:953-978.

Smith K.J, Skelton HG, Barrett TL, Lupton GP, Graham JH. Cutaneous Myofibroma. Modern Patholog.1989 Nov; 2(6) : 603-609.

Darby I, Skalli O, Gabbiani G. Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab. Investig.1990; 63:21-29.

McMenamin ME, Fletcher CD. Malignant myopericytoma: Expanding the spectrum of tumours with myopericytic differentiation. Histopathology. 2002;41:450-60.

Birendra Rai, Evodia Ludusan, Brianan McGovern, Farhana Sharif. Mandibular swelling in a 5-year-old child – mandibular myofibroma. BMJ Case Rep 2014; 2014: bcr2014203977.

Venkatesh V, Batchu PV, Jeevan Kumar KA, Mohan AP. Myofibroma – A rare entity with unique clinical presentation. J Maxillofac Oral Surg. 2015 Mar: 14(Suppl 1): 64-68.

Beck JC, Devaney KO, Weatherly RA, Koopmann Jr CF, Lesperance MM. Pediatric myofibromatosis of the head and neck. Arch Otolaryngol Head Neck Surg 1999 Jan:125:39-44.

Anita D, Karla C, Poonam S, Anita S, Shaheen S. Solitary Intra Osseous Myofibroma of the Jaw: A Case Report and Review of the Literature. Children (Basel). 2017Oct; 4(10):91.

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Published

2021-01-25

How to Cite

Bala Sundram, M. ., Retnasingam, N. R., Saripudin, B., & Mohamad Zaini, Z. (2021). Intraosseous Myofibroma of the Mandible in a 7-Year-Old Patient: A Case Report. Malaysian Journal of Paediatrics and Child Health, 27(1), 1-7. https://doi.org/10.51407/mjpch.v27i1.117