CPG – Management of Immune Thrombocytopenic Purpura – August 2006
1. INTRODUCTION Immune thrombocytopenic purpura (ITP) affects both children and adults. It is an autoimmune disorder characterised by persistent thrombocytopenia (peripheral platelet count of less than 150 x109/L) due to autoantibody binding to platelet antigen(s) causing their premature destruction by the reticuloendothelial system, in particular the spleen. In childhood, the peak age is 2-4 years, girls and boys are…